Macrosomía fetal e hipertensión arterial, un dúo olvidado.

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Reciente publicación nuestra en la Revista Cubana De Medicina General Integral (Volumen 34, Número 2 (2018): abril-junio) la cual desde hace algún tiempo  presenta un proceso de evaluación por pares (Peerreviewed) y  se encuentra ya indexada en SCOPUS (the World largest abstract and citation database of peer-reviewed literature: scientific journals, books and conference proceedings). Tomado del Sitio Web.

Esperamos sus comentarios.

Dr. Guillermo Alberto Perez Fernandez



Libro sobre predicción de la enfermedad cardiovascular. Nuestro pequeño aporte.


Aquí les dejo el link en Amazon de nuestro primer libro sobre hipertensión arterial en la adolescencia con un enfoque novedoso en la predicción cardiovascular. El segundo tomo está por salir este año.


El autor del blog.

Tendencia en la web: Cuarta definición de infarto agudo del miocardio/2018.


La “Cuarta definición de infarto agudo del miocardio” acaba de ser publicada en el último número de la Journal de la American College of Cardiology (JACC)

Sin dudas, algo que todos agradecemos.

Puede descargar el artículo aquí.

One of our latest publications on hypertension in children and adolescents. Click below.


My latest publication about Complex interactions leading to cardiovascular disease. Click below.

Commentary: Left Ventricular Hypertrophy in Pediatric Hypertension: A Mini Review. I am very proud of this publication of mine.

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Left ventricular hypertrophy in pediatric hypertension. A new publication of mine stressing this important topic just published in the medical journal Frontiers in Pediatric (peer-reviewed journal with high impact. Click on the hyperlink)

Just awaiting for your comments.


Dr. Guillermo.

1-minute read. Aged cardiovascular system early in life. A new direction to act on. 

This post has been written by Dr. Guillermo Perez and represents his personal opinion on the topic. 

“A man is as old as his arteries”                                                                      

                                Thomas Sydenham. 

Vascular aging represents a progressive process involving biochemical, enzymatic, and cellular changes of the vascular tree.

In short, early vascular aging (EVA), is defined as a vascular damage inappropriate for age. Increased arterial stiffness, dilated elastic arteries of central type and impaired endothelial function are main aspects of this process.

EVA is common in patients with hypertension and increased burden of cardiovascular risk factors. Several studies have indicated that this process starts early in life and could be programmed during foetal life or influenced by adverse growth patterns in early postnatal life.

Determinants of EVA can be classified as prenatal and postnatal factors. Prenatal factors are related to mothers’ behavior regarding food, smoking, or alcohol consumption. Some of the genetic mutations from prenatal life seem to influence the development of EVA in children, by starting even from intrauterine life without having clinical or subclinical manifestations in childhood. Posnatal factors comprise the presence of known cardiovascular risk factors that might impact negatively over life speeding up the vascular aging.

Nowadays, the early recognition of the EVA process has become the target of many investigations seeking going ahead in the early identification of individuals at cardiovascular risk.

This is and will be the smartest way to act, it is time to detect the risk early in life. When it comes to cardiovascular risk, the earlier the better. Once the disease is in place, things may turn very unfavorable for the patient and often migh be late for an efective treatment.

Thus, we have another tool to work with, kowing how to use it is key. 


1- Nilsson P, Boutouyrie P, Cunha P. Early vascular ageing in translation a: from laboratory investigations to clinical applications in cardiovascular prevention. J Hypertens. 2013;(31):1517–1526.

2- Rana S, Pugh PC, Katz E, et al. Independent effects of early-life experience and trait aggression on cardiovascular function. Am J Physiol Regul Integr Comp Physiol. 2016;311(2):R272–R286.